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filingDate 2008-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da360e5e010d5e88b69c15959b77ede6
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publicationDate 2010-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2010278801-A1
titleOfInvention Compositions comprising optimized her1 and her3 multimers and methods of use thereof
abstract The invention provides for compositions comprising engineered Her3 multimers with improved binding affinity. Such multimers include, but are not limited to, Her1/Her 3 heterodimers in which the Her3 ligand binding domain has been optimized to increase binding to Her3. The composition also can include mixtures of Her 1 homodimers, Her 3 homodimers, and Her 1/Her 3 heterodimers.
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