| abstract |
The present invention is directed to a pharmaceutical composition, and methods of use thereof, comprising at least one agent which target multiple adenosine receptors (AR) simultaneously in a stoichiometric relationship (i.e. each AR receptor is targeted to an equal extent). Aspects of the present invention relate to pharmaceutical compositions, and uses thereof, comprising at least one agent which co-activates an A 1 -adenosine receptor (A 1 -AR) and an A 2A -adenosine receptor (A 2A -AR) or a combination of at least one agent which activates an A 1 -AR and at least one agent which activates an A 2A -AR, where both the A 1 -AR and A 2A -AR are activated in a stoichiometric relationship such that the level of biological activation of A 1 -AR is approximately the same level of biological activation of A 2A -AR. Other aspects of the present invention relates to methods for the therapeutic and prophylactic treatment of cardiac dysfunction in a subject having or at risk of having a cardiac dysfunction, for example, but not limited to, for the treatment of a subject with myocardial infarction, such as acute myocardial infarction, coronary ischemia or congestive heart failure and other cardiac dysfunctions. |