http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010267042-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aec853481274ba8e8086aef44343cbab http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fbbe0fa3c6dfa895c6e29a8231d11b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef3d0d7fdf15ae476ff9b578cd186e3a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26 |
| filingDate | 2010-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ae0c630add861c8334f5be5aebdc7d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16f713f8e7dc174c90c1998b74e5388f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a28b84b4066b5410d87a7469168eed9 |
| publicationDate | 2010-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2010267042-A1 |
| titleOfInvention | Antigen-Presenting Cell Populations And Their Use As Reagents For Enhancing Or Reducing Immune Tolerance |
| abstract | The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to induce immunologic tolerance, APCs having high levels of IDO may be used to increase tolerance in the immune system, as for example in transplant therapy or treatment of autoimmune disorders. For example, APCs having high levels of IDO, and expressing or loaded with at least one antigen from a donor tissue may be used to increase tolerance of the recipient to the donor's tissue. Alternatively, APCs having reduced levels of IDO expression and expressing or loaded with at least one antigen from a cancer or infectious pathogen may be used as vaccines to promote T cell responses and increase immunity. |
| priorityDate | 2002-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 474.