http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010249431-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73d55b44219a84c850812a4488def924 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0266 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0217 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0239 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-96 |
| filingDate | 2008-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23ed5ecd630436a1199cbddf5aac537e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_914b4d9bac0513b93546ad2d7f506478 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60824ad82afd8e3e913feabaf6180682 |
| publicationDate | 2010-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2010249431-A1 |
| titleOfInvention | Process for manufacturing disulfonic acid compound, asymmetric mannich catalst, process for manufacturing beta-aminocarbonyl derivative, and novel disulfonate |
| abstract | Hexamethylphosphoramide (HMPA) was added to a reaction vessel containing (R)-1,1′-binaphthyl-2,2′-dithiol and potassium hydroxide. The vessel was purged with oxygen and stirred at 80° C. for 5 days under 7 atmospheres of oxygen. After being cooled to room temperature, the reaction product was purified to yield potassium (R)-1,1′-binaphthyl-2,2′-disulfonate. The (R)-1,1′-binaphthyl-2,2′-disulfonic acid obtained from the disulfonate and 2,6-diphenylpyridine were stirred in acetonitrile, and then the solvent was evaporated under reduced pressure. Subsequently, magnesium sulfate and distilled CH 2 Cl 2 were added to the reaction product, and the mixture was stirred at room temperature for 30 minutes. The resulting solution was cooled to 0° C. Benzaldehyde imine whose nitrogen is protected with Cbz and subsequently acetyl acetone were dropped into the solution over a period of 1 hour. The resulting mixture was further stirred at 0° C. for 30 minutes. A corresponding β-aminocarbonyl derivative was thus produced with an yield of 91% and an enantiomeric excess of 90% ee. |
| priorityDate | 2007-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 548.