| abstract |
The present invention relates to a ligand for metals, in particular lanthanides, of the general formula (I) n n n n n n n n n n A corresponds to an organic acid radical, to an alkyl or aryl ester. R1 and R2 correspond, individually and independently of one another, to an H, an alkyl radical or an aryl radical. Z1 and Z2, identical or different, are of the general formula (ZA) or (ZB): n n n n n n n n n n G represents an O, N, P, S or a C substituted independently with an H, an alkyl radical or an aryl radical. R3 to R8 correspond, individually and independently of one another, to an H, an alkyl radical or an aryl radical. The present invention also relates to co-ordinating complexes of the general formula: [Ln(L)(H2O)n] wherein Ln is a lanthanide, L corresponds to a ligand, as well as the grafting thereof to a molecule of interest and their preparation method. The present invention relates moreover to a contrast agent and a pharmaceutical composition including at least one ligand and/or complex and/or molecule of interest. |