http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010242123-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0362 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-40 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate | 2007-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e64941d24067aec3c8494f8541a6609e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9185eacf3a5f080c8089da098145286 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_927b94147973e4f9520bceb20cb9a9b2 |
| publicationDate | 2010-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2010242123-A1 |
| titleOfInvention | Models of atherosclerosis, hyperlipidemia, lipoprotein oxidation and blood vessel inflammation and methods for making and using them |
| abstract | The invention provides genetically altered fish of the family Cyprinidae, or genus Danio , including zebrafish ( Danio rerio ) and host cells from these animals, where the fish have been genetically altered to lack or have a modified gene related to lipid metabolism, for example, an ApoE, ApoAI and/or LDL-R gene. In another aspect, the invention is directed to drug design or discovery using the animal or cell models of the invention and/or wild type zebrafish, and by administering an altered diet and/or environment to the animal of invention. The invention also provides methods for screening for a compound capable of ameliorating or preventing or reversing: atherosclerosis; hyperlipidemia; lipoprotein oxidation; the accumulation of lipid in a blood vessel wall; vascular inflammation associated with lipid accumulation in a blood vessel wall; acute atherosclerosis-associated events; heart attack; stroke. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112695034-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115299502-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112111496-A |
| priorityDate | 2006-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 363.