| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b5e3952c9806d3846678feadd663c50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d189f6c03c3e63bdb3e057d1177953af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_122199c5d0ed6ab7a356a1266a55aae7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate |
2006-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71a76fc3b7475d2407e0e40a165b7ea1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07681e255d4a1a31b4bc32a4988e4afc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eba7a994241e908e83149858fc052793 |
| publicationDate |
2010-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010234463-A1 |
| titleOfInvention |
Method for Identifying Modulators of Gamma Secretase or Notch |
| abstract |
The present invention relates to methods for high throughput screening to identify selective modulators of γ-secretase. Such modulators selectively block γ-secretase activity without affecting Notch cleavage and signaling. Said methods employ the use of high content screening methodologies to measure and quantify the translocation of the Notch intracellular domain (NICD) between the nucleus and cytoplasm in cells and the activation of Notch. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10054581-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109777827-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10274481-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010322502-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016266095-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11085918-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021094604-A1 |
| priorityDate |
2005-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |