| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6fc63b89cd5e8e7d7f50a4e2beea148
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8842f72cca329551ddc14e7a0047373
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bf0ceab440a28b91d70922a4623b1ac |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-522 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate |
2009-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a2ea964a6c454146b34f6b526b63a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ba2c85f1352d50982224ab70d530f17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26ee1d70a6430cf83b2b00e9b59e6de9 |
| publicationDate |
2010-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010233213-A1 |
| titleOfInvention |
Recombinant BCG Strains with Enhanced Ability to Escape the Endosome |
| abstract |
Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8 + T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10973908-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11406702-B1 |
| priorityDate |
2004-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |