http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010222614-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46830b651781109964ac264c9d707376 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C401-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-78 |
filingDate | 2010-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaa887f491e389d2b957d16076898ada http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26eddb53a4178a7a62eac22b047a1867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d79e2904205b7e790b314b3a695f4b94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6f625a4e00eca23caa87c977a9ff66c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c063f7e0daa6919e35d00fcd3c5541b |
publicationDate | 2010-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2010222614-A1 |
titleOfInvention | Process for the preparation of calcipotriol |
abstract | A process for the preparation of calcipotriol at least including: (a) reacting a C-22 phenylsulfonyl derivative of cholecalciferol of Formula 2, wherein R 1 and R 2 are the same or different and represent hydroxyl protecting groups, with a silyl derivative of alfa-hydroxy aldehyde of Formula 3, wherein R 3 represents silyl group of formula Si(R 4 )(R 5 )(R 6 ), where R 4 -R 6 are the same or different and represent C 1-6 alkyl or phenyl groups, in the presence of a strong organic base in an aprotic solvent, followed by reductive desulfonation of the obtained diastereomeric mixture of alfa-hydroxysulfones with sodium amalgam, removal of the hydroxyl protecting groups, and purification of the product. The process leads to the formation of calcipotriol containing less than 0.3% of the (22Z)-isomer. The obtained calcipotriol is free of mercury traces. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108147954-A |
priorityDate | 2002-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.