abstract |
An active ingredient is a compound represented by the general formula [I]: n n n n n n n n n n [wherein R 1 and R 2 represent a lower alkyl group, a C 3-6 cycloalkyl group or the like, X 1 and X 2 represent methine, an Ar—Y 1 —Y 2 —Y 3 -substituted methine or the like, however either of them is an Ar—Y 1 —Y 2 —Y 3 -substituted methine, X 3 to X 8 represent methine, —N— or the like, Y 1 and Y 3 represent a single bond, —O— or the like, Y 2 represent a single bond, a lower alkylene group or the like, W represent —(O)—(CH 2 )n-(O)— or the like, n represents an integer of 1 to 4, L and Z 2 represent a single bond or a methylene group, Z 1 represents a single bond, a C 1-4 alkylene group or the like, and Ar represents an aromatic carbocyclic group or the like]. The compound acts as a melanin-concentrating hormone receptor antagonist and useful as a therapeutic agent for obesity or the like. |