http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010216656-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da86d012b0160d4bd183c16697106e6b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00608 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00596 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00659 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00427 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B60-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B60-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04 |
| filingDate | 2008-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_159572daeabf0537080a54598a83316f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eba0b86b96df4a6c15fbdc1cc727d6af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24681609cb94e46573d1c5d443bd85f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdcca91cac285d589156fdd5e1e31fe3 |
| publicationDate | 2010-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2010216656-A1 |
| titleOfInvention | Methods of enzymatic discrimination enhancement and surface-bound double-stranded dna |
| abstract | Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nuclease treatment to improve the quality of hybridization signals on high density oligonucleotide arrays. In another embodiment, the present invention provides methods of using ligation reactions to improve the quality of hybridization signals on high density oligonucleotide arrays. In yet another embodiment, the present invention provides libraries of unimolecular or intermolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific interactions between the double-stranded oligonucleotides, and peptides, proteins, drugs and RNA. In a related aspect, the present invention provides libraries of conformationally restricted probes on a solid support. The probes are restricted in their movement and flexibility using double-stranded oligonucleotides as scaffolding. The probes are also useful in various screening procedures associated with drug discovery and diagnosis. The present invention further provides methods for the preparation and screening of the above libraries. |
| priorityDate | 1994-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 738.