| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33c7c355287ac2da354f218947fd9d7e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-025 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate |
2006-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80721dbb4fec3b1fa088e3f2fca4be5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0abb8851799cd058f5a4aa4972d3b302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55db08e6b8b49a19e5e6d714b255195d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34af16d962a6edde85e8966b4b326cc6 |
| publicationDate |
2010-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010216160-A1 |
| titleOfInvention |
Method for the screening proteasome of activity-modulating agents and means for carryiing out said method |
| abstract |
An in cellulo method for the screening of proteasome activity-modulating agents, includes the following steps of:n a) bringing into contact the candidate agent with the yeast cell expressing in their nucleus a fusion protein comprising: (i) a p21 polypeptide selected from the p21 WAF1/Cip1 polypeptide and the p21[6KR] WAF1/Cip1 polypeptide; and (ii) at least one detectable protein; b) quantifying the first detectable protein in the yeast cells, at the end of at least one predetermined time interval after bringing into contact the candidate agent with the cells; c) comparing the value obtained at the step (b) with a control value obtained when the step (a) is performed in the absence of the candidate agent. |
| priorityDate |
2005-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |