| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7db088a1cef40f4f0e03a2468c1fefac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05b993887652163a78a888d6e7e41ae7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf2380e07172f31e9723231d4794ad87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e65ba57390a9b22cff12e1ade78c8ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a742ed559a188e3cb187177027829a1a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 |
| filingDate |
2008-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_986981139fd785a17115dcb05ef15125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a145298a50d48313b7a3a92bc8efffa1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39e82e9ccf3ddb59c282c17ef377c346
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b591dafce59000bfae320c166145d21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12f95716b97834dbdac26094ea1c0953 |
| publicationDate |
2010-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010209429-A1 |
| titleOfInvention |
Peptides and methods for the treatment of gliomas and other cancers |
| abstract |
The invention is based on the discovery that STM/Hop promotes proliferation of human glioblastoma-derived cells but not of normal astrocytes and that the proliferation requires the binding of STM/Hop to PrP C . The invention is directed to methods for treating cancer which rely on interfering with the Hop-PrP C interaction and to peptides, and antibodies raised against the peptides, which directly provide that interference. The invention is further based on the discovery that STI1 230-245 peptide and its human homologue Hop23o-245 provide the desired interference with the STI1/Hop-Pre interaction and inhibit the STI 1/Hop-induced proliferation of glioma and glioblastoma cells. The invention is thus further directed to methods of treating cancer that employ these peptides and functional derivatives thereof, and antibodies directed to the peptides and derivatives. The invention is further directed to means of treating cancer which involve reducing the effective amount of Hop or reducing the expression of Hop. The invention is further directed to means of alleviating or eliminating the side effects of drug therapy and radiotherapy used in treating patients with brain cancers. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009016959-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006182684-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10980892-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8710013-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9161988-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9365634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9221867-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8828925-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9713646-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9914754-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8546320-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012003299-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8921314-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9173891-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112036-A1 |
| priorityDate |
2007-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |