Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2be507c95ab1db82faf924d2dc3a3857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75e4faabd3f9bd0d678f5e757f6c1d42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3ef7d5ca0517e83a40828e87f89ff2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d01d96522f2620c9ba31263f4da1d12b |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
filingDate |
2010-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87f72963d99a9148d13dea5566a3b97e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7708066653016493c0abe515a5ed882a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c4c75f4e1ccc36c9c0d8b5b2631e7f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83e9dbbfd7406dff16a9877ba345499d |
publicationDate |
2010-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2010204085-A1 |
titleOfInvention |
Structure-based design of peptide inhibitors of amyloid fibrillation |
abstract |
The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms energetically-favorable interactions with the amino acid sequence of the steric zipper region of the target protein, and also possess a zipper-disrupting feature that disrupt the peptide stacking at the steric zipper region. This method can be used to obtain inhibitory peptides to disrupt fibril formation involving any protein for which a steric zipper sequence can be identified. The invention also provides inhibitory peptidic compounds, which can be used in pharmaceutical compositions and methods for treating polypeptide aggregation-associated diseases or conditions. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11498943-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021156316-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016122401-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102012019882-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9873718-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014039074-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3578565-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109641028-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9580469-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2994476-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113597431-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10400010-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2903999-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3921343-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2991664-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105636977-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3296315-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3296316-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102013007405-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10030056-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019234157-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014053110-A3 |
priorityDate |
2009-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |