abstract |
Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: n n n n n n n n n n a pharmaceutically acceptable salt or solvate thereof, n wherein n R 1 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl or the like, n One of R 2 and R 3 is a group of the formula: —C(═O)—Y—R 4 , n wherein Y is —NR 9 — or the like, n R 4 is optionally substituted cycloalkyl or the like, n R 9 is hydrogen or optionally substituted alkyl, n W is optionally substituted alkylene, n The other is a group of the formula: —V—R 5 , n wherein V is a bond, —O— or the like, n R 6 is hydrogen or optionally substituted alkyl, n R 5 is hydrogen, optionally substituted alkyl or the like, n X is a bond, —S—, —SO— or the like, n U is a bond or optionally substituted alkylene, n R 7 is hydrogen or optionally substituted alkyl, n Z is —S—, —O— or —NR 8 —, n R 8 is hydrogen, optionally substituted alkyl or the like. |