http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010196272-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94aac6c7c4d394e98518502a046114a8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-534 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B63-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0491 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2009-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5f9304f1676188395234cccabc8743a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68c295f04981a550277ee4cf33fe7858 |
| publicationDate | 2010-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2010196272-A1 |
| titleOfInvention | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
| abstract | The subject invention relates to the compositions for radiolabeling Diethylenetriaminepentaacetic Acid (DTPA)-dextran with Technetium-99m and for stabilizing the DTPA-dextran Cold Kit. The composition contains Stannous Chloride ions to reduce 99m Tc-pertechnetate, Ascorbic Acid to reduce stannic ions to stannous ions to maintain a reducing environment, α,α-Trehalose to add bulk and to stabilize the lyophilized composition without interfering with the radiochemical yield, and Glycine to transchelate Technetium-99m under highly acidic conditions to facilitate radiolabeling DTPA-dextran with high radiochemical purity. In addition, the invention pertains to methods for making and using the compositions. The reconstitution of the lyophilized composition by 99m Tc-pertechnetate, resulting in radiolabeled 99m Tc-DTPA-dextran in a composition between pH 3 to 4. This invention contains a Diluent vial, which when used will shift the pH to a moderately acidic pH, which would provide less pain on injection and ease-of-use to clinical practioners for adjusting its potency. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10695450-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113766952-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015013341-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9439985-B2 |
| priorityDate | 2009-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.