| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72d4aac0257a74d5f1552051d4ed001c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_952cffbd3f1a9a0f0658cccc9fdc0e5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3023c7c7afc42adaf37d8294c6882e5c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e9388ca3e5431ed56eaea044822383a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3db5f1a61581f333ec53254db555b59c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_191fc15788c76d8b4372ff36c59ed5de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adef6d304637224dba7c80d8ed1906f8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P37-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-04 |
| filingDate |
2007-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f9da2a9bbe1fae8abfe5532bad21e55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_447459abf6c1abfbc0826799f75871b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_564014eaa2ced2fca47d293bfe06689c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55bfdaa2e04b47075d9111cab2d3bc80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_323a7246314679a5cee86a793a44a549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6593e5b8f5ff1536ea963391e6934e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d81171afee27adb2b0bcbe6d4661f79c |
| publicationDate |
2010-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010190206-A1 |
| titleOfInvention |
Process for the preparation of immobilized recombinant penicillin acylase catalyst from achromobacter sp. ccm 4824 expressed in e. coli bl 21 ccm 7394 and its use for the synthesis of beta-lactam antibiotics |
| abstract |
The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic β-lactam antibiotics in the reaction mixture consisting of activated acyl-donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E. coli BL21 CCM 7394 as the biocatalyst. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115975881-A |
| priorityDate |
2007-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |