| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_baee372c55802742f9582e25c15ff11a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96472 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2008-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4f025dbf62e86bf66fcce1233333d1f |
| publicationDate |
2010-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010190184-A1 |
| titleOfInvention |
Screening method utilizing novel substrate c-ret for gamma-secretase |
| abstract |
The present invention provides a method of screening for compounds which affect the processing of c-Ret by γ-secretase. The method involves contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition containing c-Ret in the presence and absence of a candidate compound; measuring the cleavage of the c-Ret in the presence and absence of the candidate compound; selecting those candidate compounds which affect the cleavage of the c-Ret by γ-secretase; and identifying the candidate compounds selected in the previous step as compounds which affect the processing of c-Ret by γ-secretase. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9784751-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009191580-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8530181-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11136400-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010255522-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10947313-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865426-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011104171-A1 |
| priorityDate |
2007-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |