| abstract |
A compound represented by the formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof: n n n n n n n n n n n n wherein X 1 represents N and X 2 represents C, or X 1 represents C and X 2 represents N; n Y 1 represents CR 4 or N; n Y 2 represents CH or N; n wherein both Y 1 and Y 2 do not represent N at the same time; n R 1 represents (1) C3-10 branched alkyl which may be substituted or (2) —(CH 2 ) m —NR 5 R 6 ; R 2 , R 3 , and R 4 each independently represent H, C1-4 alkyl, a halo-substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, or the like; n R 5 and R 6 each independently represent C1-6 alkyl which may be substituted, or R 5 represents H, and R 6 represents C3-6 branched alkyl which may be substituted; and n Ar represents an aromatic ring which may be substituted, is useful as a pharmacologically active ingredient having a CRF antagonistic activity in preventing and/or treating neuropsychiatric diseases, diseases of peripheral organs or the like. |