| abstract |
The present invention is based on the observation that the co-activation of CDCA8 and AURKB, and their cognate interactions, play a significant role in lung-cancer progression. Accordingly, inhibiting the formation of the CDCA8-AURKB complex finds utility in the treatment of non-small-cell lung cancer. The present invention also provides methods for identifying for compounds suitable for the treatment and/or prevention non-small-cell lung cancer, using, for example, the transcriptional regulatory region of the CDCA8 or AURKB gene, as well as diagnostic and prognostic methods that utilize the expression levels of CDCA8 and/or AURKB as a determining index. |