| abstract |
Compounds having high angiogenesis inhibiting activity useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, e.g. cancer and cancer metastasis, are of formula (II), n n n n n n n n n n where A 1 is C—X 1 or N; Q 1 is -A 2 =A 3 -, or a heteroatom selected from —O—, —S—, and —N(R 10 )—; Q 2 is -A 4 =A 5 -, or a heteroatom selected from —O—, —S—, and —N(R 10 )—; provided that Q 1 and Q 2 are not heteroatoms at the same time; A 2 is C—X 2 or N, A 3 is C—X 3 or N, A 4 is C—X 4 or N, and A 5 is C—X 5 or N; Y is C 2-6 alkyl, C 3-9 cycloalkyl, C 2-7 alkenyl, C 2-7 alkynyl, C 2-6 alkoxy, C 2-7 alkenyloxy, C 2-7 alkynyloxy, or C 1-6 alkylthio; Z is a hydrogen atom, hydroxy, C 1-6 alkyl, C 3-9 cycloalkyl, or —NR 1 R 2 ; and L is selected from the formula: |