| abstract |
The present invention provides compounds having excellent 11β-HSD1 inhibitory activity. n A compound represented by the following formula (I): n n n n n n n n n n [whereinn X 1 represents an oxygen atom, or the formula —(CR 11 R 12 ) p —, etc., Y 1 represents a hydrogen atom, a hydroxyl group, etc., Z 1 represents an oxygen atom or the formula —(NR 14 )—, R 1 represents a hydrogen atom, a halogen atom, a cyano group, a C 1-4 alkyl group, a C 1-4 alkyl group substituted with 1 to 3 halogen atoms, a C 1-4 alkoxy group, a C 1-4 alkoxycarbonyl group, a carboxyl group, a carbamoyl group, or an amino group, and m represents an integer of 1 or 2, and R 2 represents a hydrogen atom or a C 1-4 alkyl group, and n represents an integer of 1 or 2]. |