| abstract |
A pharmaceutical composition for transdermal delivery comprisingn one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent;n nand wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; andn n(A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (C max ) to the average concentration (C avg ) for the physiologically active agent over the dosage interval within the range of 1 to 10. |