abstract |
The present invention relates to piperidine derivatives of formula (I) n n n n n n n n n n R represents halogen or C 1-4 alkyl;n nR 1 represents C 1-4 alkyl;n nR 2 or R 3 independently represent hydrogen or C 1-4 alkyl;n nR 4 represents trifluoromethyl, C 1-4 alkyl, C 1-4 alkoxy, trifluoromethoxy or halogen;n nR 5 represents hydrogen, C 1-4 alkyl or C 3-7 cycloalkyl;n nR 6 is hydrogen and R 7 is a radical of formula (W):n n n n n n n n n n n or R 6 is a radical of formula (W) and R 7 is hydrogen;n nX represents CH 2 , NR 5 or O;n nY represents Nitrogen and Z is CH or Y represents CH and Z is Nitrogen;n nA represents C(O) or S(O)q, provided that when Y is nitrogen and Z is CH, A is not S(O)q;n nm is zero or an integer from 1 to 3;n nn is an integer from 1 to 3;n np and q are independently an integer from 1 to 2;n nand pharmaceutically acceptable salts and solvates thereof.n n The process for their preparation and their use in the treatment of condition mediated by tachykinins. |