| abstract |
Compounds represented by Formula (I) or Formula (II), their pharmaceutically acceptable salts or hydrates n n n n n n n n n n wherein A, B and E independently represent CH 2 or CO; D represents S, NH, or NC 1-6 alkylhydrocarbyl; R represents H or R 3 ; R 1 represents H, or 1-2 same or different occurrences of radical(s) selected from the group consisting of F, Cl, Br, C 1-4 alkylhydrocarbyl, OH, OC 1-4 alkylhydrocarbyl, NO 2 , NHC(O)C 1-4 alkylhydrocarbyl, NH 2 , NH(C 1-4 alkylhydrocarbyl), N(C 1-4 alkylhydrocarbyl) 2 ; and R 2 represents F, CF 3 , H or C 1-4 alkylhydrocarbyl; are active inhibitors of TNFα. Provided are also preparation methods and uses thereof. |