Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4312a7b35719c8892121be20961aa1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40b65e8b5599c5fef964982ab007db89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec61de0dda530e1146e171d7fdbbdafd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a71809bc5c65fe91c245fec0148a15f8 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3145 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65613 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
2009-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e61f7dbba042923ce8c62fe5cd17607f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26d41081e97d151937f2beee474e654f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffb958a083ecd54bd94a9d58caa7c041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_255a7d58840262a8694e58f367aad443 |
publicationDate |
2010-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2010137408-A1 |
titleOfInvention |
Antisense antibacterial method and compound |
abstract |
A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid sequence of no fewer than 10 bases in length that is complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication. The compound binds to a target mRNA with a T m of between 50° to 60° C. The relatively short antisense compounds are substantially more active than conventional antisense compounds having a targeting base sequence of 15 or more bases. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9920085-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11020417-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10760078-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9469664-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11072793-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10202602-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10017763-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10344281-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9790499-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9278987-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11208655-B2 |
priorityDate |
2004-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |