| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfc821639098618dcb4e5ba69ebb9104
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9de20d302dd257d25edea33c2547d47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b62c9a97370bacaa2ba6be4d37a2cc2e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0406 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate |
2009-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e29358a18330e3d49b8c9c8692e355cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7083542e9e0fbbfaae4a593868f5e02e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_290f05eb5b0ce7caf5cd3fca43d0ac4e |
| publicationDate |
2010-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010111861-A1 |
| titleOfInvention |
Detection and quantification of abasic site formation in vivo |
| abstract |
A method of measuring the efficacy of an anticancer agent in generating abasic (AP) sites in DNA of cancer cells of a subject includes administering to the subject an anticancer agent that generates AP sites in at least one cancer cell and an AP endonuclease inhibitor probe. The AP endonuclease inhibitor probe includes a detection moiety for detecting the probe in the subject. The amount of probe bound to cancer cells of the subject is then measured. The amount of probe bound to cancer cells of the subject is indicative of efficacy of the anticancer agent in generating AP sites in cancer cells of the subject. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021094409-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022090455-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023131594-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023072904-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021013781-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021013783-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021013784-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021013785-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021013786-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022207628-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022207685-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022243210-A1 |
| priorityDate |
2008-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |