http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010063078-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cf645b8665267223f1c47e40260bf22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e661e410bb5ea5aa9d2ba29f01431db http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ae587697d9975b193347b0df6da47ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f9f7ccf7339a76949009e0909975609 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4442a1676b3a1a0cae80e36841e96d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20ccbdcb3f3122351819d53bf69cdc29 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2007-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_541fb2423fa76f5e325c4f5677f85676 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e77cd8e9c497ddf26a903bd08cd8390 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cc801bdc935a0aae8a43e0c31c7242c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_098d8cfc20bae15dadb494150027f2a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61164e694e947ceddfcc9dd7e48d69d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9193bcca06c7626a1ca12238abf5035e |
| publicationDate | 2010-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2010063078-A1 |
| titleOfInvention | Spirocompounds useful as modulators for dopamine d3 receptors |
| abstract | The present invention relates to novel compounds of formula (I) or salts thereof: n n n n n n n n n n whereinn A is a substituent selected in the group consisting of P, P1, P2 and P3n nwhereinn nP isn nn n n n n n n n n n P1 is n n n n n n n n n n P2 is n n n n n n n n n n P3 is n n n n n n n n n n n n p is an integer ranging from 0 to 4; n R 4 is selected in the group consisting of halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl, SF 5 and a 5- or 6-membered monocyclic heteroaryl group; and when p is an integer ranging from 2 to 4, each R 4 may be the same or different; n R 2 is hydrogen or C 1-4 alkyl; n q is 3, 4 or 5; n n is 0, 1 or 2; n X is —CR 1 R 3 — or —O—; n R 1 is selected in the group consisting of hydrogen, C 1-4 alkyl and fluorine; n R 3 is selected in the group consisting of hydrogen, C 1-4 alkyl and fluorine; n R 5 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and NR′R″; or R 5 is a phenyl group, a 5-14 membered heterocyclic group; and any of such phenyl or heterocyclic group is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; n R 6 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and NR′R″; or R 6 is a phenyl group, a 5-14 membered heterocyclic group and any of such phenyl or heterocyclic group is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; n R 7 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and NR′R″; or R 7 is a phenyl group, a 5-14 membered heterocyclic group; and any of such phenyl or heterocyclic group is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; n R 8 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and NR′R″; or R 8 is a phenyl group, a 5-14 membered heterocyclic group; and any of such phenyl or heterocyclic group is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; n R 9 is selected in the group consisting of hydrogen, a phenyl group, a heterocyclyl group, a 5- or 6-membered monocyclic heteroaryl group, and a 8- to 11-membered heteroaryl bicyclic, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy and C 1-4 alkanoyl; n R 10 is C 1-4 alkyl; n R 11 is hydrogen or C 1-4 alkyl; n R′ is H, C 1-4 alkyl or C 1-4 alkanoyl; n R″ is defined as R′; n R′ and R″ taken together with the interconnecting nitrogen atom may form a 5-, 6-membered saturated or unsaturated heterocyclic ring;n nwherein R 5 , R 6 , R 7 and R 8 are not simultaneously other than hydrogen; wherein only one R 2 group ma be different from hydrogen and wherein when n is 0, X is a group —CR 1 R 3 —; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or to enhance cognition. |
| priorityDate | 2006-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 987.