| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71d28a8ce0e41a167ed6064dd32d979c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-935
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate |
2008-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7491e293d82db729766513fc82ac3795
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91bbba98b8838cb985fc4c20aceed629
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a21025bd55a78f39573a362992ab0ba4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b83bdfb415a79cdbba76d54c6a3e5b9 |
| publicationDate |
2010-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010056807-A1 |
| titleOfInvention |
Prostaglandin synthesis and intermediates for use therein |
| abstract |
Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: n n n n n n n n n n wherein R represents an aryl group such as p-methoxyphenyl. n This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required α-side chain and then the required ω-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104710398-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113480506-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020011956-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10253011-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013026149-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113105329-A |
| priorityDate |
2008-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |