Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D301-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-48 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 |
filingDate |
2007-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f187e44aa689acb025d9665c0bf9a7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78e1183228d6fa12b39de28f46f4b015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a81171496b3a055f4e1d64eec25d820 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44e8e28b6a234730ae6eaa01af35f575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d14e33fcf941f90060ce63191417f166 |
publicationDate |
2010-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2010048909-A1 |
titleOfInvention |
Process for production of optically active-3-amino-2-hydroxypropionic cyclopropylamide derivatives and salts thereof |
abstract |
An objective of the present application is to provide an industrially practicable method for producing an optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof from an inexpensive easily-available starting material. The derivative or salt thereof is useful as an intermediate for a medicine. It is also intended by the present application to provide a useful intermediate of the derivative. The objective is attained by the following method. First, an easily-available 2-halo-3-oxopropionic acid derivative is asymmetrically reduced, and then epoxidated to produce an optically-active epoxycarboxylic acid derivative. Next, the derivative is converted into an optically-active epoxyamide derivative by reaction with cyclopropylamine, and then reacted with a nitrile to obtain an optically-active oxazolinamide derivative. Subsequently, selective acid solvolysis of the oxazoline skeleton gives the optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11549130-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111684065-A |
priorityDate |
2006-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |