| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c2589384023ff0a1cb7ca049cc57371
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9dfb1e3a4782339bb4705e5d6862031a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36e958459e9b49d2e1242c225c2187fb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-32322 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate |
2008-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43f5933a3a4ba79145b55ce0475fda01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_995fac0f03d531bf8e13260dea5ff4d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e91fbc79968e240e9d7eb0a9440e9da |
| publicationDate |
2010-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010047273-A1 |
| titleOfInvention |
Coxsackie B virus and type 1 diabetes |
| abstract |
Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction. Coxsackie virus has been detected in human pancreatic beta cells and causes insulitis. This non-destructive islet inflammation does not itself cause diabetes, but this disease will occur if viral infection is followed by a separate autoimmune response. The insulitis is mediated mainly by natural killer cells. Islets from coxsackie virus positive samples displayed reduced insulin secretion in response to glucose and other secretagogues. Virus extracted from positive islets was able to infect beta cells from human islets of non-diabetic donors, causing viral inclusions and signs of pyknosis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10780157-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013057191-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012001098-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012001099-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012001100-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2402027-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2402028-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2402029-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633468-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2583688-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10258685-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10675344-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012001101-A1 |
| priorityDate |
2007-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |