| abstract |
The invention relates to derivatives of a compound of formula I: n n n n n n n n n n wherein R 1 to R 7 and X 1 to X 6 are as defined herein. n The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid receptors (KORs). Specifically, the compounds are selective antagonists of KORs and are highly selective to KORs relative to mu and delta opioid receptors. |