| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4bf271a9458bb94ac87e4f07dcd318e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0671 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-00 |
| filingDate |
2009-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76b530fc455022ab51e9dae09b09e995
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5450c6ef00905880a603afadd4b74ddd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74f31a49c64afe211d8099635e400209
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6de604ac5c3548bc5304815a39d50471
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66d2356fabe1fce336a95a86bcd28670 |
| publicationDate |
2010-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010035298-A1 |
| titleOfInvention |
Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids |
| abstract |
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021042071-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9969979-B2 |
| priorityDate |
2002-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |