| abstract |
Compounds of general formula (I) n n n n n n n n n n n n W is chloro or fluoro; n Z is a —SO 2 YR 1 group wherein R 1 is C 3 -C 8 heterocyclyl, aryl or heteroaryl any of which may optionally be substituted with one or more substituents selected from halo, —CN, —C 1 -C 6 alkyl, —SOR 3 , —SO 2 R 3 , —SO 2 N(R 2 ) 2 , —N(R 2 ) 2 , —NR 2 C(O)R 3 , —CO 2 R 2 , —CONR 2 R 3 , —NO 2 , —OR 2 , —SR 2 , —O(CH 2 ) p OR 2 , and —O(CH 2 ) p O(CH 2 ) q OR 2 whereinn each R 2 is independently hydrogen, —C 1 -C 6 alkyl, —C 3 -C 8 cycloalkyl, aryl or heteroaryl; each R 3 is independently, —C 1 -C 6 alkyl, —C 3 -C 8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; n n Y is a straight or branched C 1 -C 4 alkylene chain; n and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. |