| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96486 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 |
| filingDate |
2007-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c358bbde8d4d2c71e3bbd62dc0d5cd1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9226336ac09dfb3026c5852bc04f4ceb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e43b9020eb237b035d27fdf923fd5ccf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_decbdf2c591fa6aa7f8aa669626b9f56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50640ae94f70e0ade746dcf896f1527f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbc05576292e78aff302c0eeb783a5f1 |
| publicationDate |
2010-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010021940-A1 |
| titleOfInvention |
Method for Determining the Activity of a Protease in a Sample |
| abstract |
There is provided a method for determining the activity of a protease in a sample. The method comprises (i) admixing said sample with a substrate, wherein the substrate has the formula (1a) wherein: R 1 is a hydrocarbyl group; R 2 is a first peptide moiety; R 3 is a second peptide moiety and X is selected from the group consisting of O, S and NH; Y 1 is a suitable substituent; Y 2 is a suitable substituent; and (ii) determining the activity of said protease by detecting the presence of a reporter having the formula H—X—R 1 , wherein: X is selected from the group consisting of O, S and NH; R 1 is a hydrocarbyl group. The substrate and reporter are useful for determining the efficacy of protease-modulators and candidate protease-modulators and in the diagnosis of a disease or disorder in a subject. |
| priorityDate |
2006-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |