| abstract |
Thiazepine derivative or a pharmacologically acceptable salt thereof having an effect of inhibiting 11β-hydroxysteroid dehydrogenase type 1 and having a formula (1): n n n n n n n n n n n n wherein in one embodiment, n R 1 represents a hydrogen atom, a C 1 -C 6 alkyl group; R 2 represents a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a C 1 -C 6 hydroxyalkyl group; R 1 represents a hydrogen atom or a C 1 -C 6 alkyl group; R 4 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group a or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group a; Substituent Group a consists of a halogen atom, a C 1 -C 6 alkyl group, a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group b; Substituent Group b consists of a halogen atom, a C 1 -C 6 alkyl group, and a C 1 -C 6 halogenated alkyl group. |