Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f4c2477bdea308bc9dec3feded37457 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
filingDate |
2008-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_713fb05cde3fe7a06d37f049b5d8e73c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29566bd61bc7342cbbccfbc63be88f36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_599a24a5f7f70c5929491b8ca1270934 |
publicationDate |
2010-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2010003747-A1 |
titleOfInvention |
Cultured xenopus laevis cell lines expressing mutant adenomatous polyposis coli gene |
abstract |
Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell lines were proven to maintain the intercellular adhesive structure, representing a phenomenon similar to polyp formation in individual organisms (mice). |
priorityDate |
2002-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |