abstract |
RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; β1- and β2 adrenergic receptors; acetylcholinesterase; Na + /K + -ATPase; and Na—K—2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention. |