| abstract |
The present invention provides compounds are disclosed herein having the formula: n n n n n n n n n n n n Wherein n is 1 or 2; m is 0 or 1; p is 0, 1 or 2; R 1 is aryl, heteroaryl or alkyl; n R 2 is C 1-6 hydrocarbyl, alkylacyl or hydroxyalkyl; R 3 is aryl, heteroaryl, or alkyl; R 4 is H, OH, —O—(C 1-6 alkyl), —NH—(C 1-6 alkyl), or oxide; n R 5 is H, halogen, C 1-6 alkyl, O—(C 1-6 alkyl), aryl, heteroaryl, —C(═O)(C 1-6 alkyl), substituted or un-substituted oxazolin-2-yl; n X═O, NH, —C(═O)— or —N═CH—; and n Each L is independently alkylene and carbonyl. n n n n n Therapeutic methods, compositions, and medicaments related thereto are also disclosed. |