| abstract |
The present invention provides methods of improving the incorporation of an implantable device into a bone of a host in need thereof. More particularly, the methods of the present invention include implanting the device into the bone of a host, wherein the device is at least partially made of a non-metallic material. Disposed on at least one surface of the device is an amount of hydroxyapatite and bisphosphonate, which in combination, are effective to reduce osteolysis and improve incorporation of the implant into the host bone compared to an implant without the hydroxyapatite and/or bisphosphonate. The present invention also provides methods for making such implants, as well as, the implants themselves. |