| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4af71bc6a1c6a968f85fbcdf6a56bf48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29150ca0910d10757537be584a8370c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9fb3d8a265b783769cd17c4b5a54d4ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69a1e4021ef50a55efb6e30316ec008a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate |
2009-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92533e421fd8e15c105631c32a0fecd6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c644f479b8c1cc7dc635670029a90552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43f95114159e9fca88cc09bb677f17d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f699539e263c1d2884b4e9bc73654512 |
| publicationDate |
2009-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009317850-A1 |
| titleOfInvention |
Crystal Structure of Human 70KD Ribosomal Protein S6 Kinase 1 Kinase Domain |
| abstract |
Crystallization of the 70 kDa ribosomal protein S6 kinase polypeptide 1 (p70S6K1) kinase domain for X-ray crystallography analysis to generate the three-dimensional structure of the p70S6K1 kinase domain is described. Further described is the use of the three 5 dimensional structure of p70S6K1 kinase domain for identifying and designing ligands or low molecular weight molecules that specifically bind to and modulate (inhibit) the kinase activity of p70S6K1. These ligands or molecules can be used for the treatment of metabolic disorders such as diabetes and for the treatment of various cancers. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10738281-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3368552-A4 |
| priorityDate |
2008-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |