Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbedaca079e9c3de218516b282c98826 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd9be6a4f33abc8c1edf6de2a32b3095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6de62f0bf4e14501b5d8f5dbe8d4869 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-554 |
filingDate |
2008-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d9c7e4e25761f3dfc9523a87b0645a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de20da2f552a037a5c890cfa4dfebbef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04a0db3952ad1327056aacae17e8f4e2 |
publicationDate |
2009-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2009317471-A1 |
titleOfInvention |
Controlled-release formulations, method of manufacture, and use thereof |
abstract |
The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt or solvate thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient and does not contain a functional coating or a lipophilic component. The present invention also provides methods of making and using the controlled-release compositions. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011212156-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013053485-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015231080-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3335711-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102198113-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011123496-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8808714-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011147025-A1 |
priorityDate |
2008-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |