| abstract |
A method of providing a cooling sensation to the skin or mucous membranes of the mouth by applying thereto a quantity of at least one chemical compound sufficient to cause a desirable degree of cooling sensation, the chemical compound comprising a compound of formula I: n n n n n n n n n n in which R 1 , R 2 are independently in either the meta- or para-position and independently comprise at least one of hydrogen, halide, C 1 -C 3 alkyl (linear or branched), halide, C 1 -C 3 alkoxy, nitro, nitrile, amide or ester; R 3 comprises at least one of C 1 -C 5 alkyl or C 1 -C 5 alkenyl groups (linear or branched), R 4 comprises at least one of hydrogen, C 1 -C 3 alkyl (linear or branched), or a halide. The cooling effect provided is in some instances superior to that achievable by any of the known commercial cooling agents. |