| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_096a1603c6abd9836906a6226c0cda78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8135e560e133961a31cd236d22ecf8b1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 |
| filingDate |
2007-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6ba4fc76eee305ee233cf3379858e78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81ea5980e045a94008155da871f3879d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34a7d2831faee233f2df75691b7d7834
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dc7fc9f3dee5e2260d5dd48e118eb3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_775a4e2e3a001d546b3e6a5ba710400b |
| publicationDate |
2009-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009311292-A1 |
| titleOfInvention |
Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions |
| abstract |
The present invention describes a process for the synthesis of S-nitrosothiols and the subsequent incorporation of these compounds in hydrophilic macromolecular compositions. By the process described herein, the S-nitrosothiols are synthesized in a device (FIG. 2 ) in a first step from the S-nitrosation reaction of their respective precursor thiols (A), promoted by a mechanical action that puts the thiols in contact with the nitrous acid formed from nitrite anions in acidic medium (B), and in a second mechanical operation, the freshly formed S-nitrosothiols are incorporated in an application vehicle (C) based on hydrophilic macromolecular compositions that increases their thermal stability. Therefore, the process under consideration combine the pre-application synthesis of S-nitrosothiols with their subsequent incorporation in delivery vehicles, with provide a relative stabilization of the S-nitrosothiols for sufficient periods so that the formulations prepared by this process may be stored in a domestic refrigerator during its time of use in its several possible applications. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114727915-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021069876-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7168958-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9445996-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019506419-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013085784-A1 |
| priorityDate |
2006-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |