| abstract |
A method for diagnosing susceptibility to diabetes in a dog, the method comprising: (a) (i) detecting in a sample from the dog the presence or absence of a genotype in any one of the following immune system genes: CTLA-4, IGF-2, IL-1α, IL-4, IL-6, IL-1O, IL-12β, IFNγ, PTPN3, PTPN15, PTPN22, TNF, or RANTES; and/or (ii) determining in a sample from the dog whether a genotype identified in Table 1 or 3A, or a genotype in linkage disequilibrium with said genotype identified in Table 1 or 3 A, is present in an insulin or IGF gene of the dog; and/or (iii) determining in a sample from the dog whether a genotype identified in Table 2 or 3B, or a genotype in linkage disequilibrium with said genotype identified in Table 2 or 3B, is absent in an insulin or IGF gene of the dog; and (b) thereby diagnosing whether the dog is susceptible to diabetes. |