| abstract |
The present invention is directed to compounds represented by the formula (1): n B-D-Z (1), wherein B represent the following formula (B-1), n n n n n n n n n n A represents an optionally substituted imidazole or pyrazole group; n n n n n n n n n n E represents the following formula (1a):n nX represents an oxygen atom, the formula: SOu, or the formula: N—R 9 ;n nY represents a carbon atom or a nitrogen atom;n nD represents an oxygen atom, a sulfur atom or the formula (1a);n nZ represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR 10 or OR 11 )] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient. |