| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f78f54ca14939aa46c042b5f8098b330 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6895 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2009-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a13c8572811517ac8d7528f356ee100e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a8109e005e2d94b274f1f473ae2e34a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_623e04fcb5a33a6fc49f2d39040b93b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d23ee11e09d250fbc4248118a4e85feb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c513c4481eb745b48bd4843d252632c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4849f13a9ea6cf931d6d66f31f5c5f91 |
| publicationDate |
2009-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009305274-A1 |
| titleOfInvention |
Method for determining azole resistance in candida glabrata |
| abstract |
There is disclosed a method for determining azole resistance in Candida glabrata . A biological sample containing Candida glabrata is obtained and a normalized mRNA level of CDR1 gene is determined using qRT-PCR. Using a microbroth dilution assay conducted at azole concentrations of about 2-8 μg/mL, a susceptible isolate of Candida glabrata is obtained. A qRT-PCR assay is employed on the susceptible isolate and an average mRNA level of CDR1 is obtained. A fold-change value for CDR1 is obtained by comparing the CDR1 mRNA level of the biological sample with that of the average mRNA level. A ≧ 2 -fold change value is indicative of an azole resistance in Candida glabrata . The present method provides a qRT-PCR assay for azole resistance that has a sensitivity of ≧90% and a specificity of ≧90%. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019119072-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111235288-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9238844-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011092385-A1 |
| priorityDate |
2008-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |