| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_64565acdcc52331729793a894d422711 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate |
2005-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37755f9051d24f1ff3d3a56c3b4043f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1ee66c7ece476139cf171b515a3883b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91d3ea65448ea25cb6e45cfe65c4d628
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e50fba57f73d9f1c11bc70eab6940558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5576afc39688df73c511b73afbdca765
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f711b8189febb106e776777c009e496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41fa93c7a776c38698fd5f3379620d74 |
| publicationDate |
2009-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009298847-A1 |
| titleOfInvention |
Manufacturing method of solid dispersion containing itraconazole |
| abstract |
The present invention relates to a method for preparing an itraconazole-containing solid dispersion. The itraconazole-containing solid dispersion according to the preparing method of the present invention has both improved solubility and rapid dissolution rate so that it has an excellent bioavailability. The itraconazole-containing solid dispersion of the present invention is also independent of pH variation of human stomach so that it can minimize the absorption variation of intra- and inter-individuals. In addition, the itraconazole-containing solid dispersion according to the preparing method of the present invention is stable for a long time. The present invention also provides an economical and environment-friendly method for manufacturing an itraconazole-containing composition because the method adds a lactic acid in a solution comprising itraconazole to decrease the amount of an organic solvent needed to dissolve itraconazole. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11344494-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012039768-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10004682-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015238616-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012039768-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012027222-A1 |
| priorityDate |
2004-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |