http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009298058-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e66070cbe19cee2a7e98dd43682126d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-90245 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5032 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2006-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_749e2bd2f4c716f7238da349e7d079a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5d4a5ba434ba14b5220accc22a1e9dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_721e5a4df8aa901946cd0dc49500de00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_188f5f36c0dd98a46ac0c754d7700d74 |
| publicationDate | 2009-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009298058-A1 |
| titleOfInvention | Inhibitors of PGHS-2Transactivator Activity |
| abstract | Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H 2 . PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-κB regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity. |
| priorityDate | 2005-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.