| abstract |
The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R 1 and R 2 is H, halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkoxy, —OR 4 , —NR 4 R 5 , —SR 4 , —C(O)R 4 , —C(O)OR 4 , —C(O)NR 4 R 5 , —N(R 4 )C(O)R 5 , —N(R 4 )C(O)OR 5 , —N(R 4 )C(O)NR 4 R 5 , —OP(O)(OR 4 ) 2 , —S(O) 2 OR 4 , —S(O) 2 NR 4 R 5 , —CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R 4 and R 5 is H or C 1-6 alkyl. X is O, S or NR 4 . Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention. |